No matter what class build you plan to use in Diablo 4 Season 10, acquiring the appropriate Mythic gear is essentially a must-have to maximize its power.
Of course, you can choose to challenge lair bosses and hope that RNG drops the specific Mythic Unique items you need, but for most players, crafting them is a more practical approach.
Yes, there are still only two ways to craft Mythic items in Diablo 4 Season 10:
In Blacksmith’s Forge Equipment tab, you can craft a random Mythic Unique by spending 2 Resplendent Sparks and 50,000,000 Diablo 4 gold for sale. Crafting equipment this way allows you to combine up to four of its affixes into more powerful Greater Affixes.
You can also craft a specific Mythic Unique item at a Jeweler, which costs 2 Resplendent Sparks, 5,000 Diablo 4 in-game gold, and specific runes. Please note that the runes required depend on Mythic item you’re crafting.
You can easily see the biggest difference between the two crafting methods lies in the runes. Yes, crafting each specific Mythic item requires a significant amount of runes, especially Legendary runes. Honestly, runes are practically everywhere in Sanctuary – you can find them on elite monsters, bosses, caches, and goblins. But if you rely solely on luck, you’ll be stuck waiting forever, as the drop rates are extremely low.
If you’re constantly running out of runes and desperately need to get the runes, you need to craft a Mythic item as quickly as possible, IGGM has good news for you! We’ll share the fastest and most efficient way to farm runes in Diablo 4 Season 10, saving you from wasting time on poor RNG!
Trading
First and foremost, the fastest way to get the specific runes you want is to trade. You can head to Diablo 4 forums to find players who have the runes you’re missing and trade directly with them.
But there’s a catch: they’re expensive. Sometimes even a single Legendary Rune can cost hundreds of millions of gold. If you’re well-stocked with gold, this is undoubtedly the fastest way to complete your rune collection. If not, don’t worry, we also offer a cheaper way to acquire them: buy IGGM cheap Diablo 4 items you need directly. Our extensive selection of runes for sale makes it easy to reach your goals and craft powerful Mythics!

Kurast Undercity
Besides that, there are still several effective ways to farm them yourself.
Currently, one of the best places to farm runes is in Kurast Undercity. Notably, using and maximizing Tribute of Harmony guarantees you’ll receive approximately eight to nine random runes per dungeon run. What’s more, you can clear it in under three minutes. However, to achieve this guaranteed return, you do need Tribute of Harmony.

If you’ve been playing for a while, you probably already have some Tributes in your inventory, so put them to good use and turn them into runes.
Of course, other types of Tributes can also drop runes at the end of farming. But if your goal is to farm runes exclusively, Tribute of Harmony is by far the most effective.
If you don’t have any Tributes of Harmony, don’t panic; there are many ways to obtain them. You can get them by challenging World Bosses, opening Whisper Caches, and even from Glittering Prym Treasure Goblins. Basically, most content has a chance to drop them.
When running Kurast Undercity, a smart way to maximize your gains is to form a three-person team and take turns using Tribute of Harmony. This way, you can save a lot of Tributes while still earning the same number of Diablo 4 runes. This method is efficient, cooperative, and perfect for group farming.
Lair Bosses
Now, if you’ve run out of Tributes or are looking for another way to farm, here’s what you can do: kill Lair Bosses. The bonus chests they drop are guaranteed to drop at least one or two higher-rarity runes.
However, you need Lair Boss Keys to open their chests, which can be expensive and time-consuming.
Whisper Caches
Another great way to farm is to open Whisper Caches. You can open caches by completing bounties on Tree of Whispers and winning Grim Favors. Each Whisper Cache is guaranteed to drop at least one random rune, as well as a chance for random Tributes and other valuable loot. So, while farming runes, you’re also accumulating Diablo 4 gold, materials, and gear.
Treasure Goblins
Treasure Goblins are also worth mentioning, especially Glittering Prym. These special goblins are guaranteed to drop multiple runes and Tributes. The only problem is that the chance of encountering a Prym is really low.
If you want to maximize your chances of encountering goblins, it’s best to make the most of March of the Goblins event. When the event is live, goblin spawn rates spike, which means your chances of getting extra runes, Tributes, and a host of other loot are even greater.
Pale Mark Vendors
Now, there’s one thing many players forget about: Pale Mark Vendors. These vendors can be found in The Den, where they sell valuable caches in exchange for Pale Marks. You automatically earn Pale Marks as you hire and level up your mercenaries. Once they reach max level, you can repeatedly earn these special tokens as rewards.
Remember to check your Mercenaries tab; you may have a significant amount of unclaimed Pale Marks there. You can exchange them for these Augment Caches, which may contain multiple Runes, Scattered Prisms, and Gem Fragments.
This is an often-overlooked but very effective way to quickly accumulate Diablo 4 runes and crafting materials without extensive monster farming. Please note that you need to have Aldkin at least tier 8 to unlock the cache; otherwise, it won’t appear in the drop pool.
Convert At The Jeweler
Finally, if you’ve completed several quests but haven’t had the luck to get the runes you need, don’t let all those extra runes sit around; go convert them at Jeweler.
You need three identical runes to generate a new random rune, and there’s a 15% chance it will be a higher-quality rune. It’s like a mini-gamble. Therefore, converting them gives you a real chance of getting those hard-to-find Legendary runes.
Now, let IGGM summarize. If you’re desperate to craft a specific Mythic, don’t hesitate to trade with IGGM. This is the quickest way to do it. But for some players, grinding Kurast Undercity is their goal. By consistently farming with your party using Tribute, completing Whisper bounties, killing bosses and goblins, and finally converting your extra runes at Jeweler, you’ve completed a complete rune-farming cycle. Stick with it, and your inventory will be filled with runes and Mythic gear before you know it!
